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For Actual physical components, including stoppers and tubing, rinsing or dilution with pyrogen-cost-free water devices is commonest. Some suppliers, including LVP producers, are using dilution to remove endotoxin from glass containers that happen to be then sterilized by other means. Just like validation for sterility, validation for endotoxin reduction need to incorporate a understanding of the endotoxin stress in addition to a satisfactory endotoxin problem.
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